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Mediator 1 ablation induces enamel-to-hair lineage conversion in mice by way of enhancer dynamics

Lack of Med1 in dental epithelia causes ectopic hair on incisors All through postnatal murine tooth maintenance, CL residing dental epithelial stem cells (DE-SCs) differentiate into Notch1 regulated SI, ameloblasts, and completely different epithelia to mineralize enamel on the incisor flooring (Fig. 1a, excessive). Intriguingly, deletion of Med1 from Krt14 expressing DE-SCs and their progenies…